Reversible Chromism of Tethered Ruthenium(II) Complexes in the Solid-State. F Martínez-Peña, S Infante-Tadeo, J Sánchez Costa*, AM Pizarro*. Inorganic Chemistry, 2023
Flavin-conjugated Pt(IV) anticancer agents. J Sánchez-Camacho, S Infante-Tadeo, AC Carrasco, S Scoditti, A Martinez, F Barroso-Bujans, E Sicilia, AM Pizarro, L Salassa*. Inorganic Chemistry, 2023.
Fast Hydrolysis and Strongly Basic Water Adducts Lead to Potent Os(II) Half-Sandwich Anticancer Complexes. S Infante-Tadeo, V Rodríguez-Fanjul, CC Vequi-Suplicy, and AM Pizarro*. Inorganic Chemistry, 2022, 61 (47), 18970-18978. DOI: 10.1021/acs.inorgchem.2c03246
This article shows how the great cytotoxicity of Os(II)-CN complexes seems to be explained by fast aquation of Os–Z bond, the basicity of Os-H2O adduct and a perfect match with sulfur atoms as we observed in DMSO, cysteine or even thioredoxin reductase in living cells.
It was also selected to be featured as a supplementary cover of issue 47
Osmium(II) Tethered Half-Sandwich Complexes: pH-dependent Aqueous Speciation and Transfer Hydrogenation in Cells. S Infante-Tadeo, V Rodríguez-Fanjul, A Habtemariam and AM Pizarro*. Chem. Sci., 2021,12, 9287-9297. This article was featured as Pick of the Week and included in the Hot Paper Collection of Chemical Science 2021. It was also selected to be featured in the front outside cover of issue 27. See an animated version of this cover in this link!
This article is part of the themed collections: 2021 Chemical Science HOT Article Collection and 2021 ChemSci Pick of the Week Collection and it has been portrayed in the Front Cover of Chemical Science. In addition, this work had a press release in IMDEA Nanociencia website and collected some media attention.
Modulating the water oxidation catalytic activity of iridium complexes by functionalizing the Cp*-ancillary ligand: hints on the nature of the active species. G Gatto, A De Palo, AC Carrasco, AM Pizarro, S Zacchini, G Pampaloni, F Marchetti*, A Macchioni*. Catalysis Science & Technology 2021, 11, 2885-2895.
Photoactive Platinum(II) Azopyridine Complexes. SJ Farley, L Salassa*, AM Pizarro, PJ Sadler*. Photochemistry and Photobiology 2021. DOI: 10.1111/php.13405.
Activation of the Ir−N(pyridine) Bond in Half-Sandwich Tethered Iridium(III) Complexes. AC Carrasco, V Rodríguez‐Fanjul, AM Pizarro*. Inorganic Chemistry 2020, 59, 16454-16466.
Structurally Strained Half-Sandwich Iridium(III) Complexes As Highly Potent Anticancer Agents. AC Carrasco, V Rodríguez‐Fanjul, A Habtemariam, AM Pizarro*. Journal of Medicinal Chemistry 2020, 63, 4005-4021.
First first-author publication by Ana. Original research from her PhD work that got highlighted in the Inside Cover of Journal of medicinal Chemistry!!
A new family of iridium half-sandwiches drug candidates has been designed that presents a structurally stable tether-ring in aqueous solution. the cationic iridium-based compounds display exceptionally potent anticancer activity. Iridium intracellular accumulation is remarkably high and the compounds unambiguously target the mitochondria, dissipating their membrane potential and triggering oxidative stress.
Unambiguous Intracellular Localization and Quantification of a Potent Iridium Anticancer Compound by Correlative 3D Cryo X‐Ray Imaging. JJ Conesa*, AC Carrasco, V Rodríguez‐Fanjul, Y Yang, JL Carrascosa, P Cloetens, E Pereiro, AM Pizarro*. Angewandte Chemie International Edition 2020, 59, 1270-1278.
Amazing work with fantastic collaborators!!
Iridium half-sandwich complex [Ir(η5:κ1-C5Me4CH2py)(2-phenylpyridine)]PF6 is extraordinarily potent in a number of cancer cells lines. By using 3D cryo soft X-ray and fluorescence tomographies, correlatively on the same cryo-preserved cell, we have unambiguously and exclusively localized and quantified our new iridium anticancer agent in the cell mitochondria.
Reversible pH-Responsive Behavior of Ruthenium(II) Arene Complexes with Tethered Carboxylate. F Martínez-Peña, S Infante-Tadeo, A Habtemariam, AM Pizarro*. Inorganic Chemistry, 2018, 57, 5657-5668.
Gold(III) bis(thiosemicarbazonate) compounds in breast cancer cells: Cytotoxicity and thioredoxin reductase targeting. V Rodríguez-Fanjul, E López-Torres, M. Antonia Mendiola, AM Pizarro*. European Journal of Medicinal Chemistry, 2018, 148, 372 – 383.
Control of Reversible Activation Dynamics of [Ru(η6-κ1-C6H5(C6H2)NH2)(XY)]n+ and the Effect of Chelating-Ligand Variation. F Martínez-Peña, AM Pizarro*. Chemistry - A European Journal, 2017, 23, 16231 – 16241.
This is the first publication of the young AMP group at IMDEA Nano. Original research by Fran that got highlighted in the Inside Cover of Chemistry!!
Working on the design of organometallic pH-dependent switches to achieve in-tumour activation. In this article we show the potential of a series of ruthenium(II) complexes to become such pH-responsive anticancer drugs.
Luminescent transition metal dichalcogenide nanosheets through one-step liquid phase exfoliation. MM Bernal, L Álvarez, E Giovanelli, A Arnáiz, L Ruiz-González, S Casado, D Granados, AM Pizarro, A Castellanos-Gomez and EM Pérez. 2D Materials, 2016, 3, 035014.
Thermal selectivity of intermolecular versus intramolecular reactions on surfaces. B Cirera, N Gimenez-Agullo, J Bjork, F Martinez-Peña, A Martin-Jimenez, J Rodriguez-Fernandez, AM Pizarro, R Otero, JM Gallego, P Ballester, JR Galan-Mascaros, and D Ecija. Nature Communications, 2016, 7, 11002.
Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells. JM Hearn, I Romero-Canelón, AF Munro, Y Fu, AM Pizarro, MJ Garnett, U McDermott, NO Carragher, PJ Sadler 2015 Proc. Natl. Acad. Sci. U. S. A. 112:E3800–5.
Cellular Accumulation, Lipophilicity and Photocytotoxicity of Diazido Platinum(IV) Anticancer Complexes. AM Pizarro, RJ McQuitty, FS Mackay, Y Zhao, JA Woods, and PJ Sadler. ChemMedChem 2014, 9, 1169.
The Potent Oxidant Anticancer Activity of Organoiridium Catalysts. Z Liu, I Romero-Canelón, B Qamar, JM Hearn, A Habtemariam, NPE Barry, AM Pizarro, GJ Clarkson and PJ Sadler. Angew. Chem. Int. Ed. 2014, 53(15), 3941.