Clinical nanothermometers

Place: conference room, IMDEA Nanociencia.

Abstract:

 Over the past decade, several methods for nano-scale temperature measurements have been developed, primarily relying on nanothermometers. In this seminar, I will introduce Anisotropy-Based Nanothermometers (ABNT) for both intracellular and extracellular temperature measurements. Since any fluorescent molecule, protein, or nanoparticle can be converted into ABNT, I will demonstrate how fluorescent markers used for imaging glioblastoma in humans can also be employed to measure tumor temperature. Imaging glioblastoma temperature is expected to help physicians improve the visualization of tumor boundaries in the future. Interestingly, under specific light conditions, these clinical nanothermometers can selectively disrupt the plasma membrane of individual cells. In summary, I will show how fluorescent markers used in the clinic can be used for either temperature imaging or inducing single cancer cell death.