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Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment. Cordani, M. Somoza, Á. Cellular and Molecular Life Sciences. Volume 76, Issue 7, (2019). Pages 1215-1242. Link

MicroRNA sensors based on gold nanoparticles. Catarina Coutinho, Álvaro Somoza. Anal. Bioanal. Chem (2018). Link

Dynamics of Individual Molecular Shuttles under Mechanical Force. Teresa Naranjo, Kateryna Lemishko, Sd Lorenzo, Alvaro Somoza, Felix Ritort, Emilio Pérez, Borja Ibarra. Nature Communications. 9 (1), 4512 (2018). Link

Behind the paper

Reprogramming Cells for Synergistic Combination Therapy with Nanotherapeutics against Uveal Melanoma. Paula Milán Rois, Alfonso Latorre, Ciro Rodriguez Diaz, Álvaro del Moral, Álvaro Somoza. Biomimetics. (2018), 3, 28. Link

Uracil grafted imine-based covalent organic framework for nucleobase recognition. Sergio Royuela, Eduardo García-Garrido, Miguel Martín Arroyo, María J Mancheño, María M Ramos, David González-Rodríguez, Álvaro Somoza, Félix Zamora, José L Segura. Chem. Communications. (2018), 54, 8729-8732. Link

Selective G-quadruplex binding by oligoarginine-Ru (dppz) metallopeptides. David Bouzada, Iria Salvadó, Ghofrane Barka, Gustavo Rama, José Martínez-Costas, Romina Lorca, Álvaro Somoza, Manuel Melle-Franco, M Eugenio Vázquez, Miguel Vázquez López. Chem. Communications. (2018) 54, 658-661. Link

Recent advances in uveal melanoma treatment. Beatriz Álvarez‐Rodríguez, Alfonso Latorre, Christian Posch, Álvaro Somoza. Med. Res. Rev. (2017), 37, 1350-1372. Link

Mechanical measurement of hydrogen bonded host-guest systems under non-equilibrium, near-physiological conditions (Highlighted in Chemistry World). Teresa Naranjo, Fernando Cerron, Belén Nieto-Ortega, Alfonso Latorre, Álvaro Somoza, Borja Ibarra, Emilio M Perez. Chem. Sci. (2017) 8, 6037-604. Link

Oligonucleotide Sensor Based on Selective Capture of Upconversion Nanoparticles Triggered by Target-Induced DNA Interstrand Ligand Reaction. Diego Mendez-Gonzalez, Marco Laurenti, Alfonso Latorre, Alvaro Somoza, Ana Vazquez, Ana Isabel Negredo, Enrique López-Cabarcos, Oscar G Calderón, Sonia Melle, Jorge Rubio-Retama. ACS Appl. Mater. Interfaces. (2017) 9, 112272-12281. Link

Copper(II)–Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers (Highlighted in Biofísica Magazine). Verónica G Vegas, Romina Lorca, Ana Latorre, Khaled Hassanein, Carlos J Gómez‐García, Oscar Castillo, Álvaro Somoza, Félix Zamora, Pilar Amo‐Ochoa. Angew. Chem. In. Ed. (2017) 56, 987-991. Link

Antibacterial Activity of DNA-Stabilized Silver Nanoclusters Tuned by Oligonucleotide Sequence (Highlighted in Biofísica Magazine). Siamak Javani, Romina Lorca, Alfonso Latorre, Cristina Flors, Aitziber L. Cortajarena, and Álvaro Somoza. ACS Appl. Mater. Interfaces, (2016) 8, 10147–10154. Link

Modified RNAs in CRISPR/Cas9: An Old Trick Works Again (Highlighted in Biofísica Magazine). Alfonso Latorre, Ana Latorre, Álvaro Somoza. Angew. Chem. In. Ed. (2016) 55, 3548–3550. Link

Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells. Antonio Aires, Sandra M Ocampo, Bruno M Simões, María Josefa Rodríguez, Jael F Cadenas, Pierre Couleaud, Katherine Spence, Alfonso Latorre, Rodolfo Miranda, Álvaro Somoza, Robert B Clarke, José L Carrascosa, Aitziber L Cortajarena. Nanotechnology. (2016), 27, 065103. Link 

Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery. Susanne Kossatz, Julia Grandke, Pierre Couleaud, Alfonso Latorre, Antonio Aires, Kieran Crosbie-Staunton, Robert Ludwig, Heidi Dähring, Volker Ettelt, Ana Lazaro-Carrillo, Macarena Calero, Maha Sader, José Courty, Yuri Volkov, Adriele Prina-Mello, Angeles Villanueva, Álvaro Somoza, Aitziber L Cortajarena, Rodolfo Miranda, Ingrid Hilger. Breast Cancer Research. (2015), 17, 1-17. Link

Gold-Coated Superparamagnetic Nanoparticles for Single Methyl Discrimination in DNA Aptamers. Maria Tintoré, Stefania Mazzini, Laura Polito, Marcello Marelli, Alfonso Latorre, Álvaro Somoza, Anna Aviñó, Carme Fàbrega, Ramon Eritja. International journal of molecular sciences. (2015) 16, 27625-27639. Link

Designed modular proteins as scaffolds to stabilize fluorescent nanoclusters (Highlighted in Biofísica Magazine). Pierre Couleaud, Sergio Adan-Bermudez, Antonio Aires, Sara H Mejías, Begoña Sot, Alvaro Somoza, Aitziber L Cortajarena. Biomacromolecules. (2015), 16, 3836-3844. Link

Detection of GNAQ Mutations and Reduction of Cell Viability in Uveal Melanoma Cells with Functionalized Gold Nanoparticles. Christian Posch, Alfonso Latorre, Michelle B. Crosby, Anna Celli, Ana Latorre, Igor Vujic, Martina Sanlorenzo, Gary A. Green, Jingly Weier, Mitchell Zekhtser, Jeffrey Ma, Gabriela Monico, Devron H. Char, Denis Jusufbegovic, Klemens,Rappersberger, Álvaro Somoza, Susana Ortiz-Urda. Biomedical Microdevices. (2015), 17, 1-9. Link

Glutathione-Triggered Drug Release From Nanostructures. Alfonso Latorre, Álvaro Somoza. Current Topics in Medicinal Chemistry. (2014) 14, 2662-2671. Link

Multifunctionalization of magnetic nanoparticles for controlled drug release: a general approach. Alfonso Latorre, Pierre Couleaud, Antonio Aires, Aitziber L. Cortajarena, Álvaro Somoza. Eur. J. Med. Chem. (2014) 82, 355–362. Link

Discovery of selective ligands for telomeric RNA G-quadruplexes (TERRA) through 19F-NMR based fragment screening. Miguel Garavís, Blanca López-Méndez, Alvaro Somoza, Julen Oyarzabal, Claudio Dalvit, Alfredo Villasante, Ramón Campos-Olivas, and Carlos González. ACS Chem. Biol., (2014) 9, 1559–1566. Link

DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics. Alfonso Latorre, Christian Posch, Yolanda Garcimartín, Susana Ortiz-Urda, Álvaro Somoza. Nanoscale (2014) 6, 7436–7442. Link

Single-point mutation detection in RNA extracts using gold nanoparticles modified with hydrophobic molecular beacon-like structures. Alfonso Latorre, Christian Posch, Yolanda Garcimartín, Susana Ortiz-Urda, Álvaro Somoza. Chem. Commun. (2014), 50, 3018-3020. Link

Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions. S. Pérez-rentero, A. Somoza, S. Grijalvo, B. Martin, I. G. Stará, I. Starý, R. Eritja. Journal of Chemistry, Volume 2013 (2013), Article ID 650610, 11 pages. PDF

Fluorescent DNA Stabilized Silver Nanoclusters as biosensors. Alfonso Latorre, Romina Lorca, Álvaro Somoza. Journal of Chemistry, Volume 2013 (2013), Article ID 631421, 6 pages. PDF

Enhanced Fluorescence of Silver Nanoclusters Stabilized with Branched Oligonucleotides. Alfonso Latorre, Romina Lorca, Félix Zamora and Álvaro Somoza. Chem. Commun., (2013) 49, 4950. Link

Synthesis and surface modification of uniform MFe2O4 (M = Fe, Mn, and Co) nanoparticles with tunable sizes and functionalities. Lourdes I. Cabrera, Álvaro Somoza, José F. Marco, Carlos J. Serna, M. Puerto Morales. Journal of Nanoparticle Research (2012) 14, 873. Link

DNA-mediated silver nanoclusters: synthesis, properties and applications. Alfonso Latorre, Álvaro Somoza. ChemBioChem (2012) 13, 951–8. Link

Interstrand interactions on DNA duplexes modified by TTF units at the 3′ or 5′-ends. S. Pérez-Rentero, I. Gállego, Á. Somoza, R. Ferreira, J. Janoušek, M. Bělohradský, I. G. Stará, I. Starý, R. Eritja. RSC Advances (2012) 2, 4069. Link

RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development. Edited by Paul H. Johnson. Álvaro Somoza. ChemMedChem. (2011) 6, 1311–1312. Link

Modified siRNAs for the study of the PAZ domain. Álvaro Somoza, Montserrat Terrazas, Ramón Eritja. Chemical Commun. (2010) 46, 4270–2. Link

Modificaciones Químicas en ARN interferente: De la investigación básica a las aplicaciones terapéuticas. Álvaro Somoza. Anales de Química. (2010) 106, 215-222. PDF

Evolution of DNA origami. Álvaro Somoza. Angew. Chem. Int. Ed., (2009) 48, 9406–8. Link

Protecting groups for RNA synthesis: an increasing need for selective preparative methods (Selected for its inclusion in RSC’s Chemical Biology issue 1, 2009). Álvaro Somoza. Chem. Soc. Rev. (2008) 37, 2668-2675. Link

The Roles of Hydrogen Bonding and Sterics in RNA Interference (Hot Paper). Alvaro Somoza, Jijumon Chelliserrykattil, Eric T. Kool. Angew. Chem. Int. Ed. (2006) 45, 4994–4997. Link

β-Hydroxysulfoxides as chiral cyclic ketone equivalents: enantioselective synthesis of polysubstituted cyclohexanones, cyclohexenones and cyclohexenediones. M. Carmen Carreño, Manuel Pérez-González, María Ribagorda, Álvaro Somoza, Antonio Urbano. Chem. Commun., (2002) 3052-3053. Link

Enantioselective Total Synthesis of Angucyclinone-Type Antibiotics Rubiginones A2 and C2. M. Carmen Carreño, María Ribagorda, Álvaro Somoza, Antonio Urbano. Angew. Chem. Int. Ed. (2002) 41, 2755–2757. Link